Question

Which of the following is orally active testosterone derivative having progestational activity

• A. Oxymesterone
• B. Dihydrotestosterone
• C. Ethisterone
• D. Nomegestrol

Answer 1

The Correct Option is C

To determine which of the listed compounds is an orally active testosterone derivative with progestational activity, let's analyze each option:

1. Oxymesterone: It is a synthetic anabolic-androgenic steroid (AAS) with no significant progestational activity. It's primarily used for its anabolic effects, making it less likely to be the correct answer.
2. Dihydrotestosterone: This is a naturally occurring androgen that is more potent than testosterone itself. It lacks progestational activity, and is not known to be structurally modified for progestational use.
3. Ethisterone: This compound is an orally active testosterone derivative known for its progestational activity. It belongs to the class of progestins, which are similar in activity to the natural hormone progesterone. Ethisterone was one of the first oral progestins used for contraceptive purposes and in hormone therapy.
4. Nomegestrol: This is a synthetic progestogen, used in hormone replacement therapy and contraception, but it is not a direct derivative of testosterone.

From this analysis, Ethisterone is the correct answer because it is specifically designed as a testosterone derivative with significant progestational activity, fitting the criteria of the question.