Step 1: Understanding melatonin secretion. Melatonin is a hormone primarily secreted by the pineal gland, a small endocrine gland located in the brain.
Step 2: Role of melatonin. Melatonin regulates the sleep-wake cycle (circadian rhythm) and is influenced by the light-dark cycle. Its secretion increases in darkness and decreases in light.
Step 3: Why other options are incorrect.
- (A) Thyrotrophs: These are cells in the anterior pituitary gland that secrete thyroid-stimulating hormone (TSH), not melatonin.
- (B) Gonadotrophs: These are pituitary cells that secrete gonadotropins like LH and FSH.
- (D) Adrenal gland: Secretes hormones like cortisol, aldosterone, and adrenaline, but not melatonin.
Match the following:
I. Alpha (α) cells [P] Glucagon
II. Beta (β) cells [Q] Somatostatin
III. Delta (δ) cells [R] Gastrin
IV. G cells [S] Proinsulin
Match the following Class and their Drug:
(1) Alkylating (P) 5-fluorouracil
(2) Platinum analog (Q) Cisplatin
(3) Antimetabolite (R) Cetuximab
(4) EGF receptor inhibitor (S) Chlorambucil