Question

Which of the following is one of the rules in Lipinski’s rule of five?

• A. A molecular weight equal to 500
• B. No more than five hydrogen bond acceptor groups
• C. No more than 10 hydrogen bond donor groups
• D. A calculated log $P$ value less than +5

Hint:

Lipinski's Rule of Five helps in predicting drug-likeness: - Molecular weight ≤ 500 Da - Log $P$ ≤ 5 - No more than 5 hydrogen bond donors - No more than 10 hydrogen bond acceptors Exceptions exist (e.g., antibiotics, natural products).

Answer 1

The Correct Option is B

Step 1: Understanding Lipinski’s Rule of Five Lipinski's Rule of Five is a set of guidelines used to predict the oral bioavailability of drug-like molecules. The rule states that a compound is more likely to be orally active if it meets the following criteria: 
1. Molecular weight ≤ 500 Da 
2. Log $P$ (partition coefficient) ≤ 5 
3. No more than 5 hydrogen bond donors (HBD) 
4. No more than 10 hydrogen bond acceptors (HBA) 

Step 2: Evaluating the Options - Option A (Incorrect): The rule specifies that the molecular weight should be less than or equal to 500, but not exactly 500.
 - Option B (Correct): One of Lipinski’s rules states that there should be no more than 5 hydrogen bond acceptor groups. 
- Option C (Incorrect): The correct limit for hydrogen bond donors is 5, not 10. 
- Option D (Incorrect): The log $P$ value should be less than or equal to 5, not less than +5. 

Step 3: Selecting the Correct Answer The correct answer is: No more than five hydrogen bond acceptor groups (Option B).