Question:
Which of the following is associated with defect in mismatch repair
Which of the following is associated with defect in mismatch repair
Updated On: Jul 16, 2025
- Hereditary NPCC
- SCID
- Bloom Disorder
- MUTYH Associated Polyposis
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The Correct Option is A
Solution and Explanation
The question asks which condition is associated with a defect in mismatch repair. Mismatch repair is a system within the cell responsible for correcting errors that occur during DNA replication. A defect in this system can lead to genetic diseases.
Let's examine each option:
- Hereditary NPCC (Non-Polyposis Colorectal Cancer): Also known as Lynch syndrome, is characterized by a higher risk of colorectal cancer due to inherited mutations affecting mismatch repair proteins. Therefore, Hereditary NPCC is associated with a defect in mismatch repair.
- SCID (Severe Combined Immunodeficiency): This is a group of rare disorders caused by mutations affecting T and B lymphocytes. It is not related to mismatch repair.
- Bloom Disorder: A rare genetic disorder that is marked by increased susceptibility to various cancers but is caused by mutations affecting DNA helicase, not mismatch repair.
- MUTYH Associated Polyposis: Involves mutations in the MUTYH gene affecting DNA repair, but it is not specifically a mismatch repair defect.
Based on the explanations, the condition associated with a defect in mismatch repair is Hereditary NPCC.
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