Question

Which of the following inhibits acetyl-coA carboxylase in fatty acid synthesis?

• A. ATP
• B. Malonyl coA
• C. Palmitic acid
• D. Glucose

Hint:

Feedback inhibition by the end product (palmitic acid) is a key regulatory mechanism in metabolic pathways such as fatty acid synthesis.

Answer 1

The Correct Option is C

Acetyl-CoA carboxylase is the rate-limiting enzyme in fatty acid synthesis. It is inhibited by palmitic acid, the final product of fatty acid synthesis, through feedback inhibition. This helps regulate the synthesis and prevent the overproduction of fatty acids.
ATP and malonyl-CoA activate acetyl-CoA carboxylase, promoting fatty acid synthesis, while glucose is not directly involved in inhibiting this enzyme.
Final Answer: \[ \boxed{\text{Palmitic acid}} \]