Question

Which of the following formulations are “pharma- ceutically equivalent"? Match the List-I with List-II

	Ingrediant		Function	Table A	Table B	Table C	Table D
A	Aceta- minophen	I	Drug	300 mg	-	300 mg	300 mg
B	Aspirin	II	Drug	-	300 mg	-	-
C	Lactose	III	Filler	100 mg	100 mg	-	100 mg
D	Avicel	IV	Filler	-	-	100 mg	-
	starch		Dis-integrant	50 mg	50 mg	-	50 mg
	Avicel		Dis-integrant	-	-	50 mg	-
	Magsterate		Lubricant	2 mg	2 mg	2 mg	2 mg
	Gelatin		Binder	10 mg	10 mg	10 mg	10 mg

Choose the correct answer from the options given below:

• A. A and B
• B. B and C
• C. A and C
• D. B and D

Answer 1

The Correct Option is C

To determine which formulations are "pharmaceutically equivalent," we need to identify formulations with identical active ingredients in the same dosage form and quantity.

In the given table, the key components are:

• Active Ingredient (Drug): Acetaminophen and Aspirin
• Inactive Ingredients: Lactose (Filler), Avicel (both as a Filler and Disintegrant), Starch (Disintegrant), Magsterate (Lubricant), Gelatin (Binder)

Let's analyze each tablet:

• Table A: Contains 300 mg Acetaminophen, 100 mg Lactose, 50 mg Starch, 2 mg Magsterate, and 10 mg Gelatin.
• Table B: Contains 300 mg Aspirin, 100 mg Lactose, 50 mg Starch, 2 mg Magsterate, and 10 mg Gelatin.
• Table C: Contains 300 mg Acetaminophen, 100 mg Avicel (Filler), 50 mg Avicel (Disintegrant), 2 mg Magsterate, and 10 mg Gelatin.
• Table D: Contains 300 mg Acetaminophen, 100 mg Lactose, 50 mg Starch, 2 mg Magsterate, and 10 mg Gelatin.

To be pharmaceutically equivalent, formulations should have the same active ingredients at the same dose and dosage form. Let's find these:

1. Table A and Table C both contain 300 mg of Acetaminophen.
2. Other components such as fillers and binders do not affect the pharmaceutical equivalence since they do not alter the therapeutic efficacy in terms of the active ingredient.

Thus, the correct answer is that Tables A and C are pharmaceutically equivalent. This matches the correct answer provided: A and C.