Question

Which of the following drugs is not likely to cause Pulmonary fibrosis?

• A. Metformin
• B. Methotrexate
• C. Bleomycin
• D. Nitrofurantoin

Answer 1

The Correct Option is A

To determine which drug is not likely to cause pulmonary fibrosis, we must recognize the common drugs associated with this condition. Pulmonary fibrosis is a lung disease that can be induced by certain medications due to their toxic effects on lung tissue. Here’s a brief explanation of each option:

• Metformin: Primarily used for type 2 diabetes management, metformin is not associated with pulmonary fibrosis. It has a different mechanism of action focused on reducing glucose production in the liver.
• Methotrexate: An immunosuppressant used for conditions such as rheumatoid arthritis and certain cancers, methotrexate can cause pulmonary toxicity, including pulmonary fibrosis, as an adverse effect.
• Bleomycin: A chemotherapeutic agent known for its potential to cause pulmonary fibrosis, particularly when used in higher doses for cancer treatment.
• Nitrofurantoin: An antibiotic that can induce pulmonary reactions, including chronic changes such as pulmonary fibrosis, especially with long-term use.

Given this information, Metformin is the correct answer as it is not associated with causing pulmonary fibrosis.