Question

Which of the following antipsychotic have increased prolactin secretion

• A. Olanzapine
• B. Ziprasidone
• C. Clozapine
• D. Risperidone

Answer 1

The Correct Option is D

In the realm of pharmacology, antipsychotic medications can have varying effects on prolactin levels. Prolactin is a hormone whose secretion can be influenced by certain medications, particularly antipsychotics, due to their action on dopamine receptors. Dopamine typically inhibits prolactin secretion, so blocking dopamine receptors can result in increased levels of prolactin.

Among the options provided:

• Olanzapine - This atypical antipsychotic may cause some increase in prolactin levels, but it's generally considered to have a lower propensity to do so compared to other antipsychotics.
• Ziprasidone - This medication has a relatively mild effect on prolactin secretion.
• Clozapine - Known for having a minimal impact on prolactin levels, making it distinctive among antipsychotics.
• Risperidone - This antipsychotic is well-documented for causing a significant increase in prolactin levels due to its potent dopamine D2 receptor antagonism.

Hence, the antipsychotic that most significantly increases prolactin secretion is Risperidone.