Question

Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase ?

• A. Imatinib and sunitinib
• B. Letrozole
• C. Bicalutamide
• D. Fulvestrant

Answer 1

The Correct Option is A

In biochemistry and pharmacology, tyrosine kinase inhibitors are a class of drugs that block the action of enzymes called tyrosine kinases, which are involved in many cellular processes, including the regulation of growth. Competitive inhibitors of tyrosine kinase specifically bind to the active site of the enzyme, blocking substrate access. Among the given options:

1. Imatinib and Sunitinib: Both are known competitive inhibitors of tyrosine kinase. Imatinib specifically targets Bcr-Abl tyrosine kinase, which is characteristic of certain leukemias, whereas Sunitinib is a broader tyrosine kinase inhibitor used in various cancers.

2. Letrozole, Bicalutamide, and Fulvestrant: These drugs function via different mechanisms. Letrozole is an aromatase inhibitor, used in hormone receptor-positive breast cancer. Bicalutamide is a non-steroidal anti-androgen, and Fulvestrant is an estrogen receptor antagonist.

Thus, the option Imatinib and Sunitinib correctly identifies the competitive inhibitors of tyrosine kinase.