Question

Which medication is added to prolong the activity of L-DOPA in the case of motor fluctuation development?

• A. MAO-B inhibitors
• B. Catechol-O-methyl transferase inhibitor
• C. Dopamine inhibitors
• D. Anti-cholinergic

Hint:

COMT inhibitors are adjuncts to L-DOPA that enhance and prolong its therapeutic effect.

Answer 1

The Correct Option is B

Catechol-O-methyl transferase (COMT) inhibitors, like entacapone, reduce the peripheral metabolism of L-DOPA, thereby extending its half-life and effectiveness in managing motor fluctuations in Parkinson’s disease.