Question

Which is the active form of Ganciclovir?

• A. Phosphate
• B. Tetraphosphate
• C. Biphosphate
• D. Triphosphate

Hint:

For nucleoside analogs like Ganciclovir, the active form is typically the triphosphate form, which is essential for its antiviral activity.

Answer 1

The Correct Option is D

The active form of Ganciclovir is Ganciclovir triphosphate. Ganciclovir is converted into its active form by the addition of three phosphate groups, allowing it to inhibit viral DNA synthesis by acting as a chain terminator.