Two key hormones stimulate the production of pancreatic juice and bicarbonate:
Cholecystokinin (CCK): This hormone is released by the small intestine in response to the presence of fats and proteins. It stimulates the pancreas to secrete enzyme-rich pancreatic juice that aids in digestion.
Secretin: This hormone is released in response to acidic chyme entering the small intestine. It stimulates the pancreas to produce bicarbonate-rich pancreatic juice to neutralize the acid.
Together, these hormones ensure the proper breakdown of food in the digestive system.