Question

Which disease will show the following mode of inheritance?

• A. Wiskott
• B. Wilson
• C. Prader-Willi
• D. Achondroplasia

Hint:

Wiskott-Aldrich syndrome is inherited X-linked recessively, which means that males are predominantly affected while females may be carriers.

Answer 1

The Correct Option is A

To determine the disease that exhibits the specified mode of inheritance, we need to examine each option through the lens of genetic inheritance patterns.

1. Wiskott-Aldrich syndrome: This disease is inherited in an X-linked recessive manner. It primarily affects males and is characterized by immunodeficiency, eczema, and thrombocytopenia. Since females have two X chromosomes, they are less likely to exhibit symptoms but can be carriers.

2. Wilson disease: This is an autosomal recessive disorder caused by mutations affecting copper metabolism. Males and females are equally affected because two copies of the defective gene are needed to exhibit the disease.

3. Prader-Willi syndrome: This disorder is related to genomic imprinting and results from a deletion or uniparental disomy on chromosome 15. It is not associated with typical Mendelian inheritance patterns like autosomal or sex-linked.

4. Achondroplasia: This common form of dwarfism follows an autosomal dominant pattern, meaning only one defective copy of the gene from either parent is sufficient to cause the condition.

Based on the descriptions provided, the correct answer that matches the described mode of X-linked recessive inheritance is Wiskott-Aldrich syndrome.