In the context of assessing an infant with a Patent Ductus Arteriosus (PDA), it is crucial to measure pre-ductal oxygen saturation to understand the infant's oxygenation status before blood has mixed through the ductus arteriosus. The pre-ductal site is typically the right upper limb. This is because the right subclavian artery, which supplies the right arm, branches off from the brachiocephalic artery before the ductus arteriosus inserts into the aorta. Therefore, to measure pre-ductal oxygen saturation in a 3-minute-old infant with suspected PDA, the fetal right upper limb is the correct site.