Question

What temperature ranges are typically used to destroy Pyrogens in Parenterals?

• A. 50° C for 10 minutes
• B. 1000° C for 15 minutes
• C. 150° C for 20 minutes
• D. 250° C for 45 minutes

Hint:

Remember: 250° C for 45 minutes is the key condition for pyrogen destruction by dry heat.

Answer 1

The Correct Option is D

Dry heat sterilization at 250° C for 45 minutes is the standard method for destroying pyrogens (endotoxins) in parenteral preparations. Pyrogens are heat-stable and cannot be removed by regular sterilization techniques like autoclaving, making high-temperature dry heat the preferred method.