Question

What is mechanism of action of colchicine in acute gout?

• A. Inhibition of purine metabolism
• B. Inhibition of uric acid conversion
• C. Migration of leukocytes
• D. Leukocytes, lymphocytes inhibition & microtubular inhibitor

Answer 1

The Correct Option is D

Colchicine is a medication used in the treatment of acute gout, and it works by disrupting the inflammatory process. The correct mechanism of action is "Leukocytes, lymphocytes inhibition & microtubular inhibitor." Here's how colchicine functions:

• Microtubular Inhibition: Colchicine binds to tubulin, a protein that forms microtubules. This binding action ultimately disrupts the assembly of microtubules, which are essential components for cell division and intracellular transport.
• Leukocyte Migration: By inhibiting microtubules, colchicine prevents the migration of leukocytes (white blood cells) to the site of inflammation in the joints. This is crucial because leukocyte infiltration is a key component in the inflammatory response associated with gout.
• Inflammatory Mediator Release: Colchicine also reduces the release of inflammatory mediators such as cytokines from leukocytes, further decreasing inflammation and pain.

By targeting these cellular processes, colchicine alleviates the inflammation and pain associated with gout attacks, making it effective for managing acute gout symptoms.