Question

What do you mean by Mendelian disorders? Give an example of an autosome-linked Mendelian disorder.

Hint:

Mendelian disorders follow inheritance patterns; examples include sickle cell anemia (autosomal recessive) and hemophilia (X-linked).

Answer 1

Mendelian disorders are genetic diseases caused by mutations in a single gene and follow Mendel’s principles of inheritance. They can be dominant or recessive.
Example: Sickle cell anemia (an autosome-linked Mendelian disorder). Mendelian disorders result from mutations in a single gene and are inherited in a predictable manner. Sickle cell anemia, an autosome-linked disorder, is caused by a mutation in the HBB gene on chromosome 11, leading to abnormal hemoglobin formation.