Step 1: Drug and Alcohol Abuse.
Drug and alcohol abuse refers to the excessive consumption of substances that can alter mental and physical functions.
Step 2: Effects on the Body.
1. Liver Damage: Alcohol abuse can lead to liver diseases such as cirrhosis and hepatitis.
2. Heart Problems: Both alcohol and certain drugs can cause cardiovascular diseases, including hypertension, heart attacks, and strokes.
3. Mental Health Disorders: Substance abuse can contribute to mental health issues like depression, anxiety, and psychosis.
4. Addiction: Drugs and alcohol can lead to physical and psychological dependence, making it difficult to quit.
5. Weakened Immune System: Long-term abuse weakens the immune system, making the body more susceptible to infections.
Step 3: Conclusion.
Both drugs and alcohol have serious long-term effects on the body, impacting various organs and overall health.
Final Answer:
\[
\boxed{\text{Drug and alcohol abuse can damage organs, cause mental health disorders, and lead to addiction.}}
\]