Question

What are the common toxicities of PARPi and how to manage them?

Hint:

Managing toxicities associated with PARP inhibitors involves dose adjustments, supportive care, and regular monitoring to ensure patient safety.

Answer 1

PARP inhibitors (PARPi) are generally well tolerated but can be associated with several toxicities, which can range from mild to severe.
Step 1: Common Toxicities:
1. Hematologic Toxicity: Common side effects include thrombocytopenia, anemia, and neutropenia. These effects are typically manageable with dose adjustments and supportive care.
2. Gastrointestinal Toxicity: Nausea, vomiting, and anorexia are commonly reported. These symptoms can be managed with antiemetic therapy.
3. Fatigue: Fatigue is a common side effect and can be managed with supportive care, including rest and symptom management.
4. Liver Toxicity: Transient increases in liver enzymes may occur but are usually reversible. Monitoring liver function is recommended during treatment.
Step 2: Management Strategies:
1. Dose Reduction: For severe toxicities, dose reduction or treatment interruptions may be necessary.
2. Supportive Care: Antiemetics, growth factors, and blood transfusions may be used to manage hematologic and gastrointestinal toxicities.
3. Liver Monitoring: Regular monitoring of liver enzymes during treatment can help detect liver toxicity early and guide management.