Question

Valproate and Carbamazepine can be used as first line drugs for the management of following type of seizure.

• A. Both partial seizure and Tonic-clonic seizure.
• B. Both Tonic-clonic seizure and Status epilepticus
• C. Only Febrile seizures
• D. Both Febrile seizures and Status epilepticus

Answer 1

The Correct Option is A

Valproate and Carbamazepine are both anticonvulsant medications used in the management of various types of seizures. To determine for which types of seizures these drugs can be used as first-line treatments, let's explore their roles in treating seizures.

1. Valproate:
   • Valproate is commonly used for generalized tonic-clonic seizures. It is effective because it enhances GABAergic activity which helps in stabilizing the hyperexcitable neurons.
   • It is also effective for partial (focal) seizures, characterized by seizures originating in one hemisphere of the brain.
2. Carbamazepine:
   • Carbamazepine is effective in treating partial seizures. It works by stabilizing the inactivated state of voltage-gated sodium channels, thereby reducing neuronal excitability.
   • It is also used for generalized tonic-clonic seizures.

Based on the above analysis, both Valproate and Carbamazepine are suitable for managing:

• Partial seizures
• Tonic-clonic seizures

Therefore, the correct option is:

Both partial seizure and Tonic-clonic seizure.

Let's eliminate the incorrect options for clarity:

• Both Tonic-clonic seizure and Status epilepticus: Although Valproate can be used in status epilepticus, Carbamazepine is not typically first-line for this condition.
• Only Febrile seizures: Febrile seizures typically occur in children due to fever, and these drugs are generally not the first line for managing febrile seizures.
• Both Febrile seizures and Status epilepticus: As mentioned, Carbamazepine is not used for status epilepticus, and neither of these are primary treatments for febrile seizures.

Thus, the statement 'Both partial seizure and Tonic-clonic seizure' is justified with the roles of Valproate and Carbamazepine in seizure management.