Question

The toxic substance released with the rupturing of RBCs during malaria fever is:

• A. Haematoxyline
• B. Haematin
• C. Haemozoin
• D. Haemin

Answer 1

The Correct Option is C

Malaria is a disease caused by the Plasmodium parasite, transmitted to humans through the bite of infected Anopheles mosquitoes. During the lifecycle of the Plasmodium parasite, it invades red blood cells (RBCs) and multiplies within them. As the parasites grow, they eventually cause the RBCs to rupture. 

The rupture of RBCs releases several substances, but the primary toxic substance is called Haemozoin. Haemozoin is a crystalline pigment formed by the Plasmodium parasite as it digests hemoglobin inside the RBCs. This substance is insoluble and accumulates in the tissues, contributing to the symptoms and pathology of malaria.

Therefore, the toxic substance released with the rupturing of RBCs during malaria is Haemozoin.

Answer 2

The toxic substance released during malaria fever when RBCs (red blood cells) rupture is Haemozoin.

Haemozoin is a waste product produced by the malaria parasite Plasmodium during its lifecycle inside the red blood cells. When the parasite breaks down hemoglobin to obtain nutrients, it produces haemozoin, which is released into the bloodstream when the RBCs rupture. This substance contributes to the fever and symptoms of malaria.

Here are the explanations for the other options:

(1) Haematoxyline: This is a dye used in histology, not a toxic substance produced by malaria.

(2) Haematin: Haematin is a form of heme (a component of hemoglobin), but it is not the substance that causes malaria symptoms.

(4) Haemin: Haemin is another derivative of heme, but it is not the substance responsible for the fever caused by malaria.

Thus, the correct answer is (3) Haemozoin.