Question

The toxic substance released with the rupturing of RBCs during malaria fever is:

• A. Haematoxyline
• B. Haematin
• C. Haemozoin
• D. Haemin

Answer 1

The Correct Option is C

The toxic substance released during malaria fever when RBCs (red blood cells) rupture is Haemozoin.

Haemozoin is a waste product produced by the malaria parasite Plasmodium during its lifecycle inside the red blood cells. When the parasite breaks down hemoglobin to obtain nutrients, it produces haemozoin, which is released into the bloodstream when the RBCs rupture. This substance contributes to the fever and symptoms of malaria.

Here are the explanations for the other options:

(1) Haematoxyline: This is a dye used in histology, not a toxic substance produced by malaria.

(2) Haematin: Haematin is a form of heme (a component of hemoglobin), but it is not the substance that causes malaria symptoms.

(4) Haemin: Haemin is another derivative of heme, but it is not the substance responsible for the fever caused by malaria.

Thus, the correct answer is (3) Haemozoin.

Answer 2

Haemozoin is a toxic byproduct produced by the malaria parasite, Plasmodium, when it digests hemoglobin. The release of haemozoin during RBC rupture leads to malaria symptoms, such as fever and chills.