Question

The quadruple therapy of Helicobacter pylori infection includes

• A. Bismuth subsalicylate, metronidazole, tetracycline and a proton pump inhibitor
• B. Streptomycin, metronidazole, tetracycline and a proton pump inhibitor
• C. Sulfasalazine, metronidazole, tetracycline and a proton pump inhibitor
• D. Bismuth subsalicylate, metronidazole, azithromycin and a proton pump inhibitor

Answer 1

The Correct Option is A

The question asks about the components of the quadruple therapy used for treating Helicobacter pylori infection. Let's analyze the given options:

• Bismuth subsalicylate, metronidazole, tetracycline, and a proton pump inhibitor
• Streptomycin, metronidazole, tetracycline, and a proton pump inhibitor
• Sulfasalazine, metronidazole, tetracycline, and a proton pump inhibitor
• Bismuth subsalicylate, metronidazole, azithromycin, and a proton pump inhibitor

The standard quadruple therapy typically includes:

1. Bismuth subsalicylate: Used as an antacid and to enhance the effect of antibiotics against H. pylori.
2. Metronidazole: An antibiotic with activity against anaerobic bacteria and certain parasites, effective in H. pylori eradication.
3. Tetracycline: An antibiotic that inhibits protein synthesis in bacteria, effectively reducing H. pylori load.
4. Proton Pump Inhibitor (PPI): Reduces gastric acid secretion, enhancing the efficacy of antibiotics by creating a less acidic environment.

Now, let's evaluate the options:

• The first option correctly lists all components of the quadruple therapy, which is Bismuth subsalicylate, metronidazole, tetracycline, and a proton pump inhibitor.
• The second option includes streptomycin, which is not a component traditionally used in H. pylori quadruple therapy.
• The third option includes sulfasalazine, which is primarily used in the treatment of inflammatory bowel diseases and does not have a role in H. pylori therapy.
• The fourth option includes azithromycin instead of tetracycline, and azithromycin is not a standard drug in the quadruple therapy for H. pylori.

Based on the components typically involved in quadruple therapy, the correct answer is:

Bismuth subsalicylate, metronidazole, tetracycline, and a proton pump inhibitor