Al$_2$O$_3$ is an amphoteric oxide, which reacts with both acids and bases:
\[\text{Al}_2\text{O}_3 + 6\text{HCl} \rightarrow 2\text{AlCl}_3 + 3\text{H}_2\text{O}.\]
\[\text{Al}_2\text{O}_3 + 2\text{KOH} + 3\text{H}_2\text{O} \rightarrow 2\text{K[Al(OH)}_4].\]
This property makes it unique among the given options.