We are given the digits \( \{0, 1, 2, 3, 4, 5\} \) and need to find the number of four-digit numbers that can be formed with at least one digit repeated.
1. Total number of four-digit numbers:
A four-digit number cannot start with 0, so we have 5 choices for the first digit (1, 2, 3, 4, or 5), and 6 choices for each of the other three digits (0, 1, 2, 3, 4, or 5):
\[
\text{Total numbers} = 5 \times 6 \times 6 \times 6 = 1080
\]
2. Number of four-digit numbers with no digits repeated:
For a four-digit number with no digits repeated, we have 5 choices for the first digit (1, 2, 3, 4, or 5), 5 choices for the second digit (remaining 5 digits), 4 choices for the third digit, and 3 choices for the fourth digit:
\[
\text{Numbers with no repetition} = 5 \times 5 \times 4 \times 3 = 300
\]
3. Number of four-digit numbers with at least one digit repeated:
To find this, we subtract the number of numbers with no repetition from the total number of numbers:
\[
\text{Numbers with repetition} = 1080 - 300 = 780
\]
Thus, the correct answer is \( \boxed{780} \).