Question:
The electron transport chain is a series of redox reactions that result in ATP synthesis. Which of the following is a cytochrome complex IV inhibitor?
The electron transport chain is a series of redox reactions that result in ATP synthesis. Which of the following is a cytochrome complex IV inhibitor?
Updated On: Jun 18, 2025
- Cyanide
- Carbon dioxide
- Oligomycin
- Ouabain
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The Correct Option is A
Solution and Explanation
Cyanide is a known inhibitor of cytochrome complex IV in the electron transport chain (ETC). This complex, also known as cytochrome c oxidase, is crucial for the transfer of electrons from cytochrome c to oxygen. Cyanide binds to the heme group of cytochrome c oxidase, inhibiting its function and preventing electron transfer to oxygen. This blockage stops ATP synthesis, as the proton gradient necessary for ATP production via ATP synthase is no longer maintained.
| Substance | Effect on ETC |
|---|---|
| Cyanide | Inhibits cytochrome complex IV |
| Carbon dioxide | No direct effect on ETC inhibition |
| Oligomycin | Inhibits ATP synthase |
| Ouabain | Inhibits Na⁺/K⁺ ATPase, not part of ETC |
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