The drug of choice in Paracetamol overdose is N-acetylcysteine (also known as Acetylcysteine). N-acetylcysteine is used as an antidote in the treatment of paracetamol (acetaminophen) overdose because it helps to prevent or reduce liver damage caused by the overdose. It works by replenishing the levels of glutathione, a natural antioxidant that helps to protect the liver from damage. Dopamine, Hydralazine, and Furosemide are not used as the drug of choice in Paracetamol overdose.