The most common method for counting blood cells in clinical hematology is the Coulter Principle, also known as the electrical impedance method.
This technique involves passing blood cells suspended in an electrolyte solution through a small aperture.
Each cell passing through the aperture momentarily changes the electrical resistance, which is detected as a pulse.
- Each pulse corresponds to one cell, and the size of the pulse can also give information about the volume of the cell.
- This principle is therefore fundamentally based on electrical conductivity or more precisely, changes in electrical impedance.
Hence, the correct principle is electrical conductivity.