Question

The correct sequence of reactions for the synthesis of the following molecule is(are) 

• A. (i) 4-Iodophenol, Mg, ether
  (ii) Cyclopropane carboxaldehyde, THF
  (iii) CsCO₃, MeI, THF
• B. (i) Cyclopropyl bromide, Mg, ether
  (ii) 4-Hydroxybenzaldehyde, THF
  (iii) CsCO₃, MeI, THF
• C. (i) 4-Iodophenol, CsCO₃, MeI, THF
  (ii) Mg, ether
  (iii) Cyclopropane carboxaldehyde, THF
• D. (i) Cyclopropyl bromide, Mg, ether
  (ii) Methyl 4-methoxybenzoate, THF

Hint:

In synthesis, carefully follow the reagent order and conditions to ensure proper functional group transformations.

Answer 1

The Correct Option is C

Step 1: Understanding the synthesis sequence.
The sequence involves the use of a Grignard reagent (generated from 4-iodophenol and Mg in ether), followed by the reaction with cyclopropane carboxaldehyde. The third step involves the methylation of the product using CsCO₃ and MeI.

Step 2: Analyzing the options.
- Option (A) correctly follows the steps involving the formation of the Grignard reagent, reaction with cyclopropane carboxaldehyde, and methylation.
- Other options are incorrect as they either do not use the correct reagents or order of reactions.

Step 3: Conclusion.
The correct sequence is (A).