The area of a parallelogram formed by two vectors is given by the magnitude of their cross product:
\[ \text{Area} = \| \vec{a} \times \vec{b} \|. \]
Compute \(\vec{a} \times \vec{b}\):
\[ \vec{a} \times \vec{b} = \begin{vmatrix} \hat{i} & \hat{j} & \hat{k} \\ 2 & -1 & 5 \\ 2 & 1 & 2 \end{vmatrix}. \]
Expand the determinant:
\[ \vec{a} \times \vec{b} = \hat{i} \begin{vmatrix} -1 & 5 \\ 1 & 2 \end{vmatrix} - \hat{j} \begin{vmatrix} 2 & 5 \\ 2 & 2 \end{vmatrix} + \hat{k} \begin{vmatrix} 2 & -1 \\ 2 & 1 \end{vmatrix}. \]
Calculate each minor:
\[ \begin{vmatrix} -1 & 5 \\ 1 & 2 \end{vmatrix} = (-1)(2) - (5)(1) = -2 - 5 = -7, \]
\[ \begin{vmatrix} 2 & 5 \\ 2 & 2 \end{vmatrix} = (2)(2) - (5)(2) = 4 - 10 = -6, \]
\[ \begin{vmatrix} 2 & -1 \\ 2 & 1 \end{vmatrix} = (2)(1) - (-1)(2) = 2 + 2 = 4. \]
Substitute back into the determinant:
\[ \vec{a} \times \vec{b} = -7 \hat{i} + 6 \hat{j} + 4 \hat{k}. \]
Find the magnitude of \(\vec{a} \times \vec{b}\):
\[ \| \vec{a} \times \vec{b} \| = \sqrt{(-7)^2 + (6)^2 + (4)^2} = \sqrt{49 + 36 + 16} = \sqrt{101}. \]
Thus, the area of the parallelogram is:
\[ \text{Area} = \sqrt{101}. \]