Murein, also known as peptidoglycan, is a polymer that forms the structural component of bacterial cell walls. In gram-positive bacteria, the cell wall is thick and consists of a high amount of murein, which accounts for approximately 50-60 percent of the cell wall's dry weight. This high concentration of murein contributes to the rigidity and structural integrity of the cell wall, which is a characteristic feature of gram-positive bacteria.
- Gram-negative bacteria have a much thinner layer of murein (around 10-20%) and an additional outer membrane.
- Gram-positive bacteria, with their thicker peptidoglycan layer, are more susceptible to certain types of antibiotics, like penicillin, which target the synthesis of this layer.