Study the pedigree chart of a family sharing the inheritance of sickle cell anemia.
The trait traced in the above pedigree chart is:
1. Perform a cross between two sickle cell carriers. What ratio is obtained between carrier, disease free and diseased individuals in F1 progeny? Name the nitrogenous base substituted, in the haemoglobin molecule in this disease.
2. Explain the difference in inheritance pattern of flower colour in garden pea plant and snap-dragon plant with the help of monohybrid crosses.
OR,
Explain with the help of well-labelled diagrams how lac operon operates in E. coli :
1. In presence of an inducer.
2. In absence of an inducer.
Study the pedigree chart given below, showing the inheritance pattern of blood group in a family:

Answer the following questions:
(a) Give the possible genotypes of individual 1 and 2.
(b) Which antigen or antigens will be present on the plasma membranes of the R.B.Cs of individuals ‘5’ and ‘8’?
The sequence of nitrogenous bases in a segment of a coding strand of DNA is
5' – AATGCTAGGCAC – 3'. Choose the option that shows the correct sequence of nitrogenous bases in the mRNA transcribed by the DNA.
Rishika and Shivika were partners in a firm sharing profits and losses in the ratio of 3 : 2. Their Balance Sheet as at 31st March, 2024 stood as follows:
Balance Sheet of Rishika and Shivika as at 31st March, 2024
| Liabilities | Amount (₹) | Assets | Amount (₹) |
|---|---|---|---|
| Capitals: | Equipment | 45,00,000 | |
| Rishika – ₹30,00,000 Shivika – ₹20,00,000 | 50,00,000 | Investments | 5,00,000 |
| Shivika’s Husband’s Loan | 5,00,000 | Debtors | 35,00,000 |
| Creditors | 40,00,000 | Stock | 8,00,000 |
| Cash at Bank | 2,00,000 | ||
| Total | 95,00,000 | Total | 95,00,000 |
The firm was dissolved on the above date and the following transactions took place:
(i) Equipements were given to creditors in full settlement of their account.
(ii) Investments were sold at a profit of 20% on its book value.
(iii) Full amount was collected from debtors.
(iv) Stock was taken over by Rishika at 50% discount.
(v) Actual expenses of realisation amounted to ₹ 2,00,000 which were paid by the firm. Prepare Realisation Account.
A carpenter needs to make a wooden cuboidal box, closed from all sides, which has a square base and fixed volume. Since he is short of the paint required to paint the box on completion, he wants the surface area to be minimum.
On the basis of the above information, answer the following questions :
Find \( \frac{dS}{dx} \).
