Question

Select the INCORRECT statement.

• A. Haemophilia is caused due to deficiency of VIII and IX clotting factor.
• B. Gene for normal clotting is present on non-homologous region of X chromosome.
• C. In haemophilia, RBCs are sickle shaped.
• D. Carrier female for haemophilia has one recessive gene on X chromosome.

Hint:

Haemophilia affects the clotting factors, while sickle cell anemia affects the shape of red blood cells.

Answer 1

The Correct Option is C

Step 1: Understanding haemophilia.
Haemophilia is a genetic disorder caused by a deficiency of clotting factors VIII or IX, located on the X chromosome. It is unrelated to the shape of red blood cells. Sickle cell anemia is a different disorder that affects the shape of RBCs.
Step 2: Analyzing the options.
(A) Haemophilia is caused due to deficiency of VIII and IX clotting factor: Correct — Haemophilia is caused by a deficiency in clotting factors VIII or IX.
(B) Gene for normal clotting is present on non-homologous region of X chromosome: Correct — The genes for clotting factors VIII and IX are located on the X chromosome.
(C) In haemophilia, RBCs are sickle shaped: Incorrect — This statement is false. Sickle-shaped RBCs are characteristic of sickle cell anemia, not haemophilia.
(D) Carrier female for haemophilia has one recessive gene on X chromosome: Correct — Carrier females have one normal and one mutated gene for haemophilia on their X chromosomes.
Step 3: Conclusion.
The correct answer is (C) In haemophilia, RBCs are sickle shaped., as it is an incorrect statement.