1. Fraenkel-Conrat (Francoise Fraenkel-Conrat) is known for showing that the genetic nature of tobacco mosaic virus (TMV) is RNA, not DNA — the phrasing in option (1) is imprecise.
2. "In vitro DNA synthesis" is associated with different investigators (e.g., Arthur Kornberg worked on DNA polymerase and in vitro DNA synthesis) — "Hanning" is not the standard attribution.
3. Watson and Crick proposed the double helical model for DNA (not RNA), so option (3) is incorrect.
4. Marshall Nirenberg deciphered aspects of the genetic code (shared Nobel Prize for cracking the genetic code). Thus option (4) is the correct historically accurate pair.
5. Therefore the correct answer is (4) Genetic code - Marshall Nirenberg.