Question

Salt and Pepper pot appearance of skull seen in:

• A. Hyperparathyroidism
• B. Multiple myeloma
• C. Hyperthyroidism
• D. Pseudo hyperparathyroidism

Answer 1

The Correct Option is A

In the field of radiodiagnosis and radiotherapy, understanding the radiographic appearances associated with various conditions is crucial. One such classic radiographic appearance is the "Salt and Pepper pot" appearance of the skull. This specific pattern is linked with:

Hyperparathyroidism

Let's explore why this is the case:

• Hyperparathyroidism: This condition results in increased parathyroid hormone production, leading to increased bone resorption and subsequent bone demineralization. Radiologically, the skull shows a mottled appearance due to the irregular resorption of bone, akin to the scattered grains of salt and pepper. This pattern results from both trabecular bone resorption and new bone formation.
• Other Options:
  • Multiple myeloma: While multiple myeloma also affects the skull, it typically presents with lytic lesions rather than a 'salt and pepper' pattern.
  • Hyperthyroidism: Does not characteristically affect the skull in the described 'salt and pepper' manner; instead, it affects bone density more generally.
  • Pseudo hyperparathyroidism: Although it mimics hyperparathyroidism in lab results, the 'salt and pepper' skull appearance is not a common descriptor for this condition.

In summary, the 'salt and pepper' appearance of the skull is most accurately associated with Hyperparathyroidism.