Question

Prostaglandin analogous have therapeutic utility in the following EXCEPT

• A. Impotence
• B. Peripheral vascular disease
• C. Palliative treatment of patent ductus arteriosus
• D. Palliative treatment of patent ductus arteriosus

Answer 1

The Correct Option is C

To determine the condition for which prostaglandin analogs do not have therapeutic utility, we need to understand the role of these compounds in medical treatments.

• Impotence: Prostaglandin E1 analogs, such as alprostadil, are utilized in the treatment of erectile dysfunction. They help by increasing blood flow to the penis, aiding in achieving and maintaining an erection.
• Peripheral vascular disease: Prostaglandins are used in peripheral vascular diseases due to their vasodilatory effects, which improve blood flow and alleviate symptoms associated with these conditions.
• Palliative treatment of patent ductus arteriosus (PDA): PDA is generally treated using prostaglandin inhibitors to close the ductus arteriosus. Prostaglandin analogs, conversely, are used to keep the ductus arteriosus open temporarily in certain congenital heart defects until surgical correction can be performed. Hence, they are not used for palliative treatment aimed at closure of PDA.

Based on the above explanations, prostaglandin analogs are not used in the Palliative treatment of patent ductus arteriosus as this would counteract their intended function of closure. Instead, drugs like NSAIDs, which inhibit prostaglandin synthesis, are employed for this purpose. Therefore, the correct answer is the option where prostaglandin analogs are not therapeutically useful.

Thus, the exception is:

• Palliative treatment of patent ductus arteriosus