Question

Primary Hypertriglyceridemia:
Causes.

Hint:

Genetic testing can help identify inherited causes of hypertriglyceridemia, guiding treatment strategies.

Answer 1

Primary hypertriglyceridemia is a genetic condition characterized by high levels of triglycerides in the blood. The causes are typically related to inherited disorders.
Step 1: Genetic Factors:
1. Familial Hypertriglyceridemia: This is the most common inherited cause, resulting from a genetic mutation that affects lipid metabolism.
2. Familial Combined Hyperlipidemia: This condition involves elevated triglycerides and cholesterol levels, often due to multiple genetic factors.
3. Lipoprotein Lipase Deficiency: A rare inherited disorder that leads to a deficiency in the enzyme lipoprotein lipase, which is essential for triglyceride metabolism.
4. Apolipoprotein C-II Deficiency: This condition leads to impaired lipoprotein lipase function, resulting in high triglyceride levels.