Question

Peripheral chemoreceptors respond to hypoxia using which channel?

• A. Calcium channel
• B. Sodium channel
• C. Potassium channel
• D. Chloride channel

Answer 1

The Correct Option is C

Peripheral chemoreceptors are specialized sensory receptors sensitive to changes in the partial pressures of oxygen in the blood. These receptors are primarily located in the carotid bodies and play a vital role in respiratory regulation.

These receptors respond to hypoxia (low oxygen levels) by modulating the activity of specific ion channels in their cell membranes. The essential ion channel involved in this response is the potassium channel.

Under normal oxygen conditions, potassium channels remain open, allowing the flow of potassium ions out of the cell. This helps maintain a stable resting membrane potential. However, when oxygen levels drop:

• The activity of potassium channels is inhibited.
• Potassium ions accumulation causes cell depolarization.
• Depolarization leads to the opening of voltage-gated calcium channels.
• Influx of calcium ions results in the release of neurotransmitters.
• These neurotransmitters activate afferent neurons, signaling the brain to increase respiratory rate and depth.

This series of events illustrates how potassium channels are crucial in the hypoxic response of peripheral chemoreceptors.

Thus, the correct answer is: Potassium channel.