Question

Ochronosis is due to the accumulation of?

• A. Homogentisic acid
• B. Homogentisic acid
• C. Xanthurenate
• D. Glyoxylate

Answer 1

The Correct Option is A

Ochronosis is a condition characterized by the bluish-black discoloration of certain tissues, such as skin or cartilage, which is typically associated with alkaptonuria. Alkaptonuria is a rare genetic disorder that leads to the disruption of tyrosine metabolism. This disruption is caused by a deficiency in the enzyme homogentisate 1,2-dioxygenase.

The deficiency of this enzyme results in the accumulation of homogentisic acid in the body. As this acid builds up, it binds to collagen in connective tissues, leading to the distinctive dark pigmentation characteristic of ochronosis.

The correct answer to the question about the cause of ochronosis is Homogentisic acid, as this acid's accumulation leads to the symptoms associated with the condition.

Therefore, the correct response is:

Homogentisic acid