Question

Niacin therapy is contraindicated in diabetes because

• A. Increases the blood sugar levels
• B. Causes scleroderma
• C. Difficult to give injection
• D. Increases the metabolism of oral hypoglycemic drugs

Answer 1

The Correct Option is A

Niacin therapy, also known as nicotinic acid or vitamin B3 therapy, is commonly used for its beneficial effects on lipid profiles, particularly in increasing high-density lipoprotein (HDL) cholesterol levels. However, it is contraindicated in patients with diabetes mellitus. The primary reason for this contraindication is due to niacin's effect on blood glucose levels.

Niacin can cause an increase in blood sugar levels, a significant consideration in diabetic patients who must maintain tight control over their glycemic status. The mechanism behind this effect may involve the interference of niacin with insulin secretion or action, leading to decreased insulin sensitivity or altered hepatic glucose production. For patients managing diabetes, any medication that exacerbates hyperglycemia can complicate disease management and increase the risk of complications.

Given these effects, the correct answer to the question regarding why niacin therapy is contraindicated in diabetes is: Increases the blood sugar levels.