Question

Name the drug that acts on both the marked areas.

• A. Sacubitril
• B. Omapatrilat
• C. Losartan
• D. Nesiritide

Answer 1

The Correct Option is B

The question asks for the identification of a drug that acts on two specific marked areas, referring to the depicted mechanism of action within a pharmacological context. Among the options provided, let's evaluate their mechanisms to identify the correct choice:

• Sacubitril: This drug is a neprilysin inhibitor, often combined with valsartan, and primarily works by increasing the levels of natriuretic peptides, bradykinin, and adrenomedullin, leading to reduced vasoconstriction, sodium retention, and maladaptive remodeling.
• Omapatrilat: This is a dual inhibitor of both angiotensin-converting enzyme (ACE) and neprilysin. By inhibiting both pathways, it addresses two physiological mechanisms—a reduction in angiotensin II levels and an increase in natriuretic peptides levels. This dual action is uniquely aligned with the requirement to act on both marked areas.
• Losartan: A selective angiotensin II receptor antagonist that primarily blocks the AT1 receptor. Its action is specific to one pathway and does not encompass multiple systems as required by the question.
• Nesiritide: A recombinant form of human B-type natriuretic peptide (BNP) that directly increases cyclic GMP in vascular smooth muscle, leading to vasodilation, but it does not address multiple mechanisms.

From this analysis, Omapatrilat is the correct answer as it simultaneously targets both ACE and neprilysin, thus acting on the two required mechanisms as depicted in the question.