Question

Mycoplasma is resistant to

• A. Ceftriaxone
• B. Cephalosporins
• C. Aminoglycosides
• D. Fluoroquinolones

Answer 1

The Correct Option is A

Mycoplasma is a genus of bacteria that is unique due to the absence of a cell wall. Because of this characteristic, Mycoplasma species are inherently resistant to antibiotics that target cell wall synthesis. Let's analyze each of the options to determine why Mycoplasma is resistant to them:

Ceftriaxone: Ceftriaxone is a type of cephalosporin which works by interfering with cell wall synthesis. Since Mycoplasma lacks a cell wall, ceftriaxone is ineffective against it.

Cephalosporins: Similar to ceftriaxone, cephalosporins block the synthesis of the bacterial cell wall. Mycoplasma's lack of a cell wall renders these antibiotics ineffective.

Aminoglycosides: Although aminoglycosides target bacterial protein synthesis machinery, Mycoplasma can show resistance due to their unique cellular structures and different ribosomal RNA compared to other bacterial species.

Fluoroquinolones: These antibiotics inhibit DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication. Mycoplasma can sometimes develop resistance through mutations.

In conclusion, Mycoplasma is inherently resistant to antibiotics like ceftriaxone and cephalosporins due to their mode of action on cell wall synthesis, aligning with the correct answer: Ceftriaxone.