Question

Mechanism of action of propyl thiouracil ………

• A. Inhibition of thyroid peroxidase
• B. Activation of thyroid peroxidase
• C. Inhibition of thyroid oxidase
• D. Activation of thyroid oxidase

Hint:

PTU blocks thyroid hormone synthesis via thyroid peroxidase inhibition.

Answer 1

The Correct Option is A

Propylthiouracil (PTU) inhibits thyroid peroxidase, thereby blocking the iodination of tyrosine residues in thyroglobulin, an essential step in thyroid hormone synthesis. It also inhibits peripheral conversion of T4 to T3.