Question

Mechanism of action of digoxin …………………………….

• A. Inhibition of sodium-potassium pump
• B. Increasing cGMP
• C. Decreasing cGMP
• D. Decreasing calcium levels

Hint:

Digoxin → inhibits Na\textsuperscript{+}/K\textsuperscript{+} pump → more Ca\textsuperscript{2+} → stronger heart contraction.

Answer 1

The Correct Option is A

Digoxin exerts its action by inhibiting the Na\textsuperscript{+}/K\textsuperscript{+}-ATPase pump in myocardial cells. This leads to an increase in intracellular Na\textsuperscript{+}, which subsequently increases intracellular Ca\textsuperscript{2+} via the Na\textsuperscript{+}/Ca\textsuperscript{2+} exchanger, enhancing cardiac contractility.