Question

Mechanism of action of curare like drugs?

• A. Blocks ACh synthesis
• B. Blocks ACh receptors
• C. Persistent depolarization
• D. Agonistic with Ach receptors

Answer 1

The Correct Option is B

Curare-like drugs are a class of neuromuscular blocking agents that are primarily used to cause muscle relaxation. The mechanism of action of these drugs involves the blockade of acetylcholine (ACh) receptors at the neuromuscular junction, which is crucial for muscle contraction. Here is a detailed explanation:

• Acetylcholine Receptors: At the neuromuscular junction, acetylcholine is the neurotransmitter responsible for transmitting nerve impulses to muscles, triggering their contraction. It achieves this by binding to nicotinic acetylcholine receptors on muscle cells.
• Action of Curare-like Drugs: Curare-like drugs act as competitive antagonists at these nicotinic acetylcholine receptors. By binding to these sites, they effectively block acetylcholine from attaching to these receptors.
• Mechanism of Blockade: This blockade prevents the depolarization of the muscle membrane, which is a necessary step for muscle contraction. As a result, the muscles become relaxed and unable to contract, leading to paralysis.
• Medical Use: These drugs are often used in surgical procedures to provide muscle relaxation or during mechanical ventilation to facilitate intubation.

The correct response to the question about the mechanism of action of curare-like drugs is:

Blocks ACh receptors