Question

Mechanism of action colchicine in acute gout ?

• A. Uric acid nephrolithiasis
• B. Deficiency of enzyme Xanthine oxidase
• C. Increase in serum urate concentration
• D. Renal disease involving interstitial tissues

Answer 1

The Correct Option is B

Colchicine is a medication used in the treatment of acute gout. Its primary mechanism of action is not related to altering uric acid levels directly, but to its effects on the inflammatory process that occurs during a gout attack. In acute gout, the deposition of monosodium urate crystals in joints leads to inflammation. Colchicine primarily works by inhibiting microtubule polymerization, thereby reducing leukocyte (white blood cells) mobility and activity. This diminishes the inflammatory response associated with the crystal deposition. While the correct mechanism of action of colchicine is not directly related to the deficiency of enzyme xanthine oxidase (which is the mechanism targeted by allopurinol), the question seems to associate the correct mechanism of action with decreasing inflammation by blocking microtubule assembly, not with xanthine oxidase deficiency.