Question

MC location of gastrinoma in MEN-1 syndrome?

• A. Duodenum
• B. Jejunum
• C. Pancreas
• D. Ileum

Answer 1

The Correct Option is A

In the context of MEN-1 syndrome, gastrinomas are most commonly located in the duodenum. MEN-1 syndrome, also known as Multiple Endocrine Neoplasia type 1, is characterized by the presence of tumors in endocrine glands, among other manifestations. Gastrinomas are neuroendocrine tumors that secrete gastrin, leading to excessive gastric acid production and recurrent peptic ulcers, a condition known as Zollinger-Ellison syndrome. When considering the potential locations of gastrinomas in MEN-1 syndrome, the following options are provided:

• Duodenum
• Jejunum
• Pancreas
• Ileum

Of these options, the most common location is the duodenum. This is because, in MEN-1 syndrome, these gastrin-secreting tumors predominantly arise in the duodenum, rather than other parts of the small intestine or pancreas. Therefore, the correct answer is:

Duodenum