LIST I (Condition) | LIST II (Characteristics) |
---|---|
A. Color blindness | I. Insensitivity to green and red light |
B. Hemophilia B | II. Deficiency of clotting factor IX |
C. Hemophilia A | III. Deficiency of clotting factor VIII |
D. G-6-PD deficiency | IV. Severe anemic condition |
- Color blindness: Results from insensitivity to green and red light, caused by mutations in opsin genes on the X chromosome.
- Hemophilia B: Caused by a deficiency in clotting factor IX, leading to prolonged bleeding.
- Hemophilia A: Caused by a deficiency in clotting factor VIII, also resulting in excessive bleeding.
- G-6-PD deficiency: Affects red blood cell metabolism, leading to anemia under oxidative stress.
List I | List II |
---|---|
(A) Radiation hybrid mapping | (I) DNA can be cut into large fragments and circularized for use in chromosome walking |
(B) Sequence tagged site (STS) mapping | (II) Useful for cloning of overlapping DNA fragments (restricted to about 200 kb) |
(C) Chromosome jumping | (III) Fragment genome into large pieces and locate markers and genes |
(D) Chromosome walking | (IV) Applicable to any part of DNA sequence if some sequence information is available |