Question

Match List-I with List-II 

Choose the correct answer from the options given below: 
 

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Associate major bioinformatics organizations with their flagship tools and databases: \textbf{NCBI} (USA): GenBank, PubMed, BLAST, \textbf{Cn3D}. \textbf{ExPASy}/SIB (Swiss): Swiss-Prot, \textbf{DeepView} (Swiss-PdbViewer). \textbf{EBI} (Europe): EMBL-Bank, InterPro, \textbf{PROCHECK}. \textbf{PDB} (Worldwide): The global archive for 3D structural data of biological macromolecules.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
This question requires matching various bioinformatics software tools with their primary source, developer, or associated database/portal. These tools are used for molecular visualization and structural analysis.
Step 2: Detailed Explanation:
(B) Cn3D: This is a 3D molecular structure viewer that is developed and distributed by the NCBI (National Center for Biotechnology Information). It is particularly well-integrated with NCBI's other resources. So, (B) matches with (II).
(C) DeepView (Swiss-PdbViewer): This is a very popular protein visualization and analysis tool. It was developed at the Swiss Institute of Bioinformatics (SIB) and is prominently featured on the ExPASy (Expert Protein Analysis System) proteomics server. So, (C) matches with (III).
(D) PROCHECK: This is a classic program used to assess the stereochemical quality of a protein structure, for example, by generating a Ramachandran plot. It was developed by Roman Laskowski and colleagues, with major versions distributed by resources at the EBI (European Bioinformatics Institute). So, (D) matches with (IV).
(A) WebMol: This is a molecular viewer designed to display structures from the PDB (Protein Data Bank). While many viewers use PDB files, WebMol has a direct association as a tool for viewing PDB data. Given the other confirmed matches, this is the logical pairing. So, (A) matches with (I).
Step 3: Final Answer:
The correct matching is: (A)-(I), (B)-(II), (C)-(III), (D)-(IV). This corresponds to option (1).