Step 1: Check the linear independence of the set \( \{u_1, u_2, u_3, u_4\} \).
To check if a set of vectors is linearly independent, we set up the equation:
\[
c_1 u_1 + c_2 u_2 + c_3 u_3 + c_4 u_4 = 0,
\]
where \( c_1, c_2, c_3, c_4 \) are scalars. The equation expands to:
\[
c_1 (1, 0, 0, -1) + c_2 (2, 0, 0, -1) + c_3 (0, 0, 1, -1) + c_4 (0, 0, 0, 1) = (0, 0, 0, 0).
\]
This gives the following system of equations:
\[
\begin{aligned}
c_1 + 2c_2 &= 0,
c_3 &= 0,
-c_1 - c_2 - c_3 + c_4 &= 0,
-c_1 - c_2 - c_3 + c_4 &= 0.
\end{aligned}
\]
Solving this system of equations, we find that the only solution is \( c_1 = c_2 = c_3 = c_4 = 0 \). Thus, the set \( \{u_1, u_2, u_3, u_4\} \) is linearly independent.
Final Answer:
\[
\boxed{\{u_1, u_2, u_3, u_4\} \text{ is linearly independent in } \mathbb{R}^4.}
\]