Question

IV administration of which anesthetic drug is most painful among the following?

• A. Methohexital
• B. Ketamine
• C. Propofol
• D. Etomidate

Answer 1

The Correct Option is C

In the context of intravenous (IV) administration of anesthetic drugs, pain upon injection is an important consideration for both patient comfort and drug selection. Among the listed options, Propofol is known to cause significant pain during IV administration. This is attributed to its formulation, which includes a lipid vehicle that can irritate the walls of veins.

In comparison:

• Methohexital - an ultra-short-acting barbiturate that typically causes less discomfort upon injection.
• Ketamine - known for its analgesic properties, generally does not cause pain upon injection and is even used to alleviate pain.
• Etomidate - while it can cause some discomfort or burning sensation during injection, it is generally considered less painful than Propofol.

Therefore, out of the options provided, Propofol is the anesthetic drug most commonly associated with pain upon IV administration.